REF-137 · Mølmen et al., 2025 · Medicine & Science in Sports & Exercise, Vol. · Paper

A Moderate-Intensity Interval Training Block Improves Endurance Performance in Well-Trained Cyclists

B+moderate evidenceMeasured on highly trained athletesWritten before October 2026, being re-checked

Participants

n=30 well-trained male cyclists, VO2max 70.5 ± 4.6 ml/kg/min. Each performed both conditions (randomized crossover).

Protocol

MIT block vs time-matched regular training (REG) in the general preparation phase:

MIT blockREG (regular training)
Duration7-day microcycle + 6-day active recovery period, then testingtime-matched
Interval sessions6 sessions in 7 daysregular preparatory routine, mostly low intensity; guideline: 2 MIT sessions, or 1 MIT + 1 HIT session, per week
Format5-7 × 10-14 min work intervals—
Intensity (RPE)prescribed 14-15 (Borg 6-20); achieved 14.4 ± 0.3—
% PO-VO2max66 ± 5%—
% HRmax85 ± 3%—
Lactate2.8 ± 1.1 mmol/L—
TRIMP1944 ± 4361800 ± 232 (P = 0.27, not different)

Key point: intensity = moderate, not high: 66% of power at VO2max, 85% HRmax, lactate 2.8 mmol/L. Interval work per session 50-98 min (5-7 × 10-14 min, arithmetic).

Key Findings

MeasureMIT blockREGp-value
PO4mmol+4.0 ± 4.4%-1.3 ± 3.7%p<0.01
PO-VO2max (1-min peak in incremental test)+2.5 ± 4.5%-0.7 ± 3.9%p<0.01
VO2max+2.0 ± 3.9%0.0 ± 3.5%p=0.05
PO15min+3.9 ± 8.3%+0.2 ± 6.8%p=0.14 (ns)

Primary result: with the same training impulse (TRIMP not different), the MIT block improved power at 4 mmol/L, peak incremental power and VO2max more than regular training in cyclists with VO2max 70.5.

Comparison with a HIT block

Not from this paper: the same group later compared a one-week MIT block with a one-week HIT block directly in a crossover of 22 well-trained cyclists — see REF-421 (Rønnestad 2025): both blocks raised 15-min power with no difference between them; the MIT block gained more at 4 mmol/L, the HIT block tended to protect sprint power. The MIT block there used the same 6-sessions-in-7-days, 5-7 × 10-14 min format.

Mechanism

Inference, not tested in this paper: six sessions of long, moderate intervals in seven days concentrate a large volume of work near the first-to-second-threshold range at low lactate, followed by six days of recovery — the block principle at a moderate intensity. The abstract reports outcomes only; no signalling, recovery or fatigue markers.

Practical Application

One 7-day block of 6 moderate-intensity sessions (5-7 × 10-14 min at RPE 14-15 — achieved 14.4, ~66% of power at VO2max, ~85% HRmax, lactate ~2.8 mmol/L) followed by 6 days of active recovery raised power at 4 mmol/L +4.0 ± 4.4% vs −1.3 ± 3.7% for time-matched regular training (p<0.01), peak incremental power +2.5% (p<0.01) and VO2max +2.0% (p=0.05) in n=30 well-trained male cyclists (VO2max 70.5), with no difference in TRIMP; 15-min power did not change significantly (+3.9% vs +0.2%, p=0.14).
Prescribe the intensity by feel and lactate, not by a fraction of FTP: "hard but manageable", RPE 14-15, lactate around 3 mmol/L. Inference, not tested: if reps drift to threshold lactate the block has become a HIT block with a different recovery cost.
The block is the whole prescription — 6 sessions in 7 days AND the 6 active-recovery days afterwards; testing happened after the recovery period.
Use it where threshold power is the priority and neuromuscular fatigue is unwanted (general preparation phase, as studied); for the head-to-head against a HIT block see REF-421; for the 12-week block-periodization evidence see REF-136.

Limitations

Only males. VO2max 70.5 ml/kg/min — transfer to less trained riders not tested. PO15min did not reach significance (p=0.14). Single MIT prescription (RPE 14-15) — other RPE targets not tested. General preparation phase only. Crossover with a time-matched control period; no long-term follow-up.

How this entry was checked and changed
Why this level

regraded 2026-09-27 from A: crossover, n=30

Content correction 2026-09-27
"Sessions long (50-100 min interval work per week)" -> per session, 50-98 min (5-7 × 10-14 min).
"REG: 13 days standard" -> abstract: time-matched regular training, mostly low intensity, with a guideline of 2 MIT or 1 MIT + 1 HIT session per week; TRIMP added (1944 vs 1800, P=0.27).
Companion-paper table (5 × 8.75 min, RPE 17.1, 90% HRmax, ~7 mmol/L, "2× lower RPE and lactate", "same improvement") -> not this paper; replaced by a pointer to REF-421 with the claims that entry actually carries (HIT lactate/HR values are not in REF-421 either and were dropped).
"RPE 14-15 = below threshold, LT1-LT2 transition", "MASSIVE effect", "elite level!" -> inference/editorial, removed or labelled.
Tier "4-5 (Elite/International)" -> Tier 3: abstract says well-trained; VO2max 70.5 fits highly trained/national.