REF-160 · Zanini et al., 2025 · Medicine & Science in Sports & Exercise, Vol. · Paper

Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners

Blimited evidenceMeasured on trained athletesWritten before October 2026, being re-checked

Participants

n=26 male runners, two groups of 13, pair-matched for performance:

LDT (long-distance training): regular long runs ≥90 min
SDT (short-distance training): all runs <70 min
Matched by: 10 km time (39:10 vs 39:00 min:s); VO2max 56.6 vs 58.9 mL/kg/min

Protocol

Preliminary tests: lactate threshold and VO2max
Test: 90-min run at lactate threshold, respiratory gases every 15 min
Neuromuscular: isometric squat peak force and countermovement jump (CMJ) before and after the run

Key Findings

ParameterLDT (long runs)SDT (no long runs)P
Running-economy change at 90 min+3.1%+6.0%<0.001
Isometric squat peak force-12.2%-19.4%0.002
CMJ mean power+2.2%-6.6%0.011
Changes in running economy came earlier and were larger in SDT than LDT.
The neuromuscular decrements were not correlated with RE durability.
RE durability correlated with the length of the weekly longest run (r=-0.67, P<0.001) and with weekly training volume (r=-0.48, P=0.038). These are simple correlations, not independent predictors from a multivariable model.

Mechanisms

Inference, not tested in this study — possible reasons regular long runs could protect economy:

1

Repeated exposure to running in progressive fatigue (recruitment and substrate adaptations).

2

Neuromuscular fatigue resistance — although in this study the neuromuscular losses did not track RE durability, so this route is not supported by these data.

3

Connective-tissue and substrate adaptations to regular long loads.

Practical Application

Cross-sectional: 26 well-trained male runners pair-matched on 10 km time (39:10 vs 39:00) and VO2max — over a 90-min run at lactate threshold, running economy worsened +3.1% in those doing regular ≥90-min long runs vs +6.0% in those whose runs were all <70 min; RE durability correlated with the length of the weekly longest run (r=-0.67) and weekly volume (r=-0.48). Association, not a trial.
The weekly long session earns its place as durability training: what it tracks is how much economy survives late in a long effort, which no interval session measures.
The correlate was the length of the longest weekly run, not how often long runs were done. Inference, not tested: progress its duration toward the target event's demands.
Squat force and jump power fell more in the no-long-run group, but those losses did not explain the economy difference — do not sell strength work as the mechanism behind this finding.
Do not swap the long session for two shorter ones when durability is the goal (REF-159).
Running data only: transfer to cycling is a reasoned extrapolation, not tested here.

Limitations

Cross-sectional and matched, not randomised. Runners who do long runs may differ from those who do not in ways that matching on 10 km time and VO2max cannot remove. The authors state intervention studies are needed.
26 well-trained males only — no women, no masters, no recreational runners.
A single 90-min test at lactate threshold measures economy drift over 90 min, not race durability over three hours.
The difference is between groups: nothing shows that adding long runs to a no-long-run athlete produces the long-run profile.
How this entry was checked and changed
Why this level

regraded 2026-09-27 from B+: cross-sectional pair-matched groups, n=26

Content correction 2026-09-27
"90-min moderate run" -> 90-min run at lactate threshold.
"Long-run frequency and weekly volume = independent predictors"; "frequency is the variable that correlated" -> simple correlations with the LENGTH of the weekly longest run (r=-0.67) and weekly volume (r=-0.48).
"LONG-RUN group more economical at baseline"; "better preserves neuromuscular function → durability" -> baseline claim removed (not in abstract); neuromuscular losses were larger in SDT but not correlated with RE durability.
Sport cycling/running/strength -> running; Level B+ -> B per rubric (cross-sectional); Tier 2-3 -> 2.
Descriptions of REF-144 repeated its pre-2026-09-26 version (muscle biopsies, glycogen/fibre-type depletion, fat oxidation doubling, power "preserved/maintained" at 100 g/h). The corrected entry took no biopsies and reports 6-min power FALLING ~10% after 4 h at 100 g/h; descriptions updated.
Revision 2026-10-16: cross-reference added to REF-1144 (Zanini 2025, the same lab's strength-training RCT on economy durability; a different paper from this one).