REF-531 · Kissow, Jacobsen, Gunnarsson, Jessen & Hostrup, 2022 · Sports Medicine, Vol. · Paper

Menstrual-Cycle Phase-Based Resistance Training (follicular vs luteal)

Muscle strength & mass

C+thin evidenceMeasured on a mixed groupWritten before October 2026, being re-checked

Key Findings

Estrogen and progesterone fluctuations across the cycle regulate protein metabolism and recovery in skeletal muscle and may therefore affect training outcomes
Studies demonstrate that anaerobic capacity and muscle strength are greatest during the follicular phase, when estrogen peaks
Studies indicate that follicular-phase-based resistance training may be superior to luteal-phase-based training for enhancing muscle strength and mass — the review sets out why this is "possibly" so and identifies directions for further research
Full text; not checked against the abstract: the supporting trials are few and small (frequency-based designs concentrating sessions in the follicular phase), and cycle-phase verification is weak in most of them

Practical Application

Narrative critical review arguing that follicular-phase-based resistance training is possibly superior to luteal-phase-based training for strength and mass, on the grounds that strength and anaerobic capacity peak in the follicular phase with estrogen; the authors call it a possibility needing further research, not an established effect. The evidence pool behind it is small — treat phase-based programming as an optional experiment.
Not from this paper; the base's own practice: a sensible n-of-1 approach — track strength and well-being by phase; if the follicular phase feels subjectively stronger, volume can be shifted there; do not impose a complex phase scheme as mandatory
Contrast with REF-335 (McNulty meta-analysis): the pooled effect of cycle phase on performance is trivial and study quality low — the reason the base keeps this at equipoise
Not from this paper: phase verification in any self-experiment needs hormonal confirmation, not just a calendar (REF-337 methodology)

Limitations

Narrative review, no systematic method or pooled effect sizes; the abstract states the hypothesis, not the data
Few high-quality RCTs; protocol heterogeneity; weak cycle-phase verification in most included works (full text; not checked against the abstract)
Mostly young eumenorrheic women — not masters/not on OC
How this entry was checked and changed
Why this level

regraded 2026-09-27 from B: narrative review without systematic method; the abstract carries no data

Content correction 2026-09-27
"Review conclusion: the evidence is LIMITED and AMBIGUOUS; other studies — NO difference" -> the abstract argues that follicular-phase-based training is possibly superior and that strength peaks in the follicular phase; the equipoise framing is the base's (via REF-335), now stated as such. Named trials (Sung 2014, Wikström-Frisén 2017) are not in the abstract and were folded into a labelled full-text note.
Level B -> C+ per KB-LEVEL-RUBRIC (narrative review without systematic method). n-of-1 tracking advice labelled as the base's own practice.
Cross-references to duplicate stubs repointed to their canonical entries (REF-526->REF-335); the stubs were emptied on 2026-09-27.