REF-973 · Drake et al., 2013 · Journal of Clinical Sleep Medicine, Vol. · Paper · PubMed

Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed

Blimited evidenceMeasured on a mixed groupWritten before October 2026, being re-checked

Sleep hygiene advice is widely given although few systematic studies have tested its empirical basis in the home environment. This study compared a fixed dose of caffeine (400 mg) taken at 0, 3 and 6 hours before habitual bedtime with placebo, using self-reported sleep at home and a validated portable sleep monitor.

Caffeine at each of the three times significantly disturbed sleep relative to placebo. The authors conclude that caffeine taken 6 hours before bedtime has important disruptive effects and that this supports refraining from substantial caffeine use for a minimum of 6 hours before bedtime.

Participants

Not described in the abstract (no sample size, age or sex).

Protocol

Fixed dose of caffeine (400 mg) at 0, 3 and 6 hours prior to habitual bedtime, compared with placebo.
Self-reported sleep in the home, plus objective monitoring with a validated portable sleep monitor.

Key Results

Caffeine at bedtime, 3 hours before bedtime or 6 hours before bedtime each had significant effects on sleep disturbance relative to placebo (p < 0.05 for all).
The authors point to the magnitude of the reduction in total sleep time with caffeine taken 6 hours before bedtime; the size of that reduction is not given in the abstract.

Practical Application

A fixed 400 mg dose of caffeine taken at bedtime, 3 hours before or 6 hours before habitual bedtime each significantly disturbed sleep compared with placebo (p < 0.05 for all), measured at home with a diary and a portable sleep monitor; the abstract gives no sample size. To "how late can I have caffeine?": this study supports stopping substantial caffeine a minimum of 6 hours before bed — and 6 hours was still not enough to leave sleep untouched.
The 6-hour figure is a floor, not a safe line: the earliest time tested still disturbed sleep, and no longer interval was tested.
Inference, not tested here: a caffeinated evening session or late race carries a sleep cost that night; smaller doses were not studied, so the cost of a single gel or a small coffee is unknown from this paper.
Not from this paper; the base's own practice: the caffeine dose for performance is in REF-350, and the evening cut-off the assistant uses is in SYNTH-07.

Limitations

The abstract gives no sample size, no participant description and no numerical size of the sleep loss.
One dose (400 mg), not scaled to body mass; habitual caffeine use is not described.
Not athletes; no exercise and no next-day performance.
No interval longer than 6 hours was tested.
Written from the abstract and record metadata only (full text not read).
How this entry was checked and changed
Why this level

placebo-controlled; sample size and randomisation are not given in the abstract