REF-1624 · Ralston, Kilgore, Wyatt, Buchan & Baker, 2018 · Sports Medicine - Open · Paper · PubMed · Free full text

Training a lift on more days a week did not clearly add strength, and with weekly volume equated it showed no difference: across 74 training groups from 12 studies, higher versus lower frequency gave a non-significant effect size of 0.09 (95% CI −0.06 to 0.24; p = 0.25), and volume-equated 1 day versus 3 or more days a week gave 0.03 (−0.20 to 0.27; p = 0.78); only upper-body lifts gained more at 3 or more days than at 1 (0.48, 0.20 to 0.76), a comparison the abstract does not describe as volume-equated, while lower-body lifts showed no significant difference between 3 or more days and 1 day (p = 0.22)

Main caveat: Abstract only; no risk-of-bias assessment reported, and no heterogeneity or funnel-plot results given.
moderate evidenceMeasured on non-athletes to trained athletesRead from the abstract only

Ralston and colleagues pooled studies of how many days a week resistance training is done and asked whether more days build more strength. They set three bands, low (1 day a week), medium (2 days) and high (3 or more days), and pooled 74 treatment groups from 12 studies with a random-effects model.

Across combined multi-joint and isolation exercises, higher frequency leaned ahead of lower but not significantly. When weekly volume was the same, gains at 1 day and at 3 or more days did not differ (effect size 0.03).

Upper-body lifts gained more at 3 or more days than at 1 day; 2 days against 1 showed no clear difference for the upper body, and the lower body showed no significant difference between 3 or more days and 1 day. A medium-versus-high contrast leaned one way without reaching significance.

The authors conclude that, in a mixed population, the data do not tie more weekly days strongly to larger strength gains, that frequency had no significant effect once volume was equated, and that more studies are needed.

Participants

74 treatment groups from 12 studies; a "mixed population group" (the authors' term), with an untrained-only analysis named in the methods. Not in the abstract and not in the PubMed indexing (the record has no MeSH headings): sex, age, total number of participants and training levels.

Protocol

Search: terms "strength training frequency", "resistance training frequency", "training frequency" and "weekly training frequency"; 12 studies met pre-set criteria. Databases and dates: not in the abstract.
Frequency bands: low (LF) 1 day a week; medium (MF) 2 days; high (HF) 3 or more days.
Questions: strength per exercise by frequency; 1RM profiles for multi-joint and single-joint exercises; volume-equated comparisons; upper versus lower body.
Main-effect analyses named in the methods: volume-equated studies combining multi-joint and isolation exercise; isolation-only exercise; untrained participants only. Results of the last two: not in the abstract.
Analysis: random-effects pooling; I² and Cochran's Q; funnel plots for publication bias; subgroup sensitivity analyses.
Not in the abstract: risk of bias, heterogeneity values, funnel-plot findings, study durations, loads and sets.
Interests: the authors declare no competing interests.

Key Results

ComparisonEffect size (95% CI); p
Higher vs lower frequency, multi-joint and isolation combined0.09 (−0.06 to 0.24); p = 0.25
1 day vs 3+ days a week, volume equated0.03 (−0.20 to 0.27); p = 0.78
Upper body, 3+ days vs 1 day0.48 (0.20 to 0.76); p < 0.01
Upper body, 2 days vs 1 day0.12 (−0.22 to 0.47); p = 0.48
Lower body, 3+ days vs 1 day0.21 as printed (−0.55 to 0.13); p = 0.22
2 days vs 3+ days (body region not named in this sentence)0.41 (−0.26 to 1.09); p = 0.23
Lower body: the printed interval does not contain the printed estimate, so a minus sign was probably lost (our reading: −0.21); either way the interval crosses zero and no frequency difference was shown.
Medium versus high: the authors call it a trend; the abstract does not say which band was ahead.
Upper body, 3+ days vs 1: the abstract does not say whether this comparison was volume-equated.
Isolation-only and untrained-only analyses: named in the methods; results not in the abstract.

Practical Application

With weekly volume equated, the number of days made no clear difference. Strength gains at 1 day and at 3 or more days a week did not differ (0.03, interval −0.20 to 0.27). Inference, not tested here: the sets can be bunched or spread as the endurance week allows.
For the legs, no significant difference was shown. The lower-body comparison of 3 or more days with 1 day crossed zero. Inference, not tested here: a cyclist or runner can put the week's lower-body sets into one or two gym days around key sessions, provided the weekly set total is kept.
The upper-body advantage may be extra volume, not extra days. Upper-body lifts gained more at 3 or more days than at 1 day (0.48), but the abstract does not say volume was equated there (our reading).
No difference shown is not proof of none. Twelve studies with wide intervals; the abstract does not let one rule out a small benefit of more days. A later model in the base reports strength rising with weekly frequency, with diminishing returns, in models adjusted for duration and training status but not stated to hold volume fixed (REF-1477), so the two can disagree for that reason alone (our reading).
Maintenance is a different question. Holding strength in season is covered by trials of reduced frequency: one session a week held strength and sprint in professional soccer players while one every second week did not (REF-1628).
Not from this paper: the 2009 ACSM position stand recommends 2-3 days a week for novices, 3-4 for intermediate and 4-5 for advanced lifters (REF-1627); ACSM's 2026 stand, built on an overview of systematic reviews, has at least 2 sessions a week raising strength (REF-1476). This pooling does not show that more days add strength once volume is matched.

Limitations

Abstract only; no risk-of-bias assessment reported, and no heterogeneity or funnel-plot results given.
Twelve studies; the body-region intervals are wide.
The lower-body estimate and its interval are inconsistent as printed (a likely lost minus sign).
Who was studied (sex, age, training level) is not in the abstract or the indexing.
Only the combined volume-equated comparison is reported as volume-equated; the upper-body result may mix frequency with volume.
Strength only; muscle size was not analysed.
How this entry was checked and changed
Why this level

risk of bias not read (abstract only): the abstract reports no risk-of-bias or quality assessment and gives neither the heterogeneity values nor what the funnel plots showed; 12 studies, with wide intervals in the body-region comparisons

Content correction 2026-11-06
2026-11-06: added from the abstract and the PubMed record; level B+ (meta-analysis of 12 studies; risk of bias not read, abstract only).