REF-1640 · Benito et al., 2016 · PLoS One · Paper · PubMed

Of three 45-min weight circuits at 70% of 15RM, the one alternating free weights with aerobic exercise drew the most oxygen (29.9 ± 3.6 ml/kg/min, against 24.2 ± 2.8 for free weights and 20.4 ± 2.9 for machines) with the lowest lactate and perceived exertion; the anaerobic share of energy was small in all three (2.3-6.2%)

Main caveat: The participants are not described in the abstract: number, sex, age and fitness unknown.
limited evidenceMeasured on a mixed groupRead from the abstract only

Benito and colleagues measured the oxygen uptake and the total energy expenditure, aerobic plus anaerobic, of three circuit weight-training sessions of equal length.

In random order, participants completed three circuits of 3 sets of 8 exercises lasting 45 min 15 s at 70% of their 15-repetition maximum: one of free weights, one of machines, and one of free weights alternated with aerobic exercise. Oxygen uptake and blood lactate were measured through each circuit to estimate the aerobic and anaerobic energy.

Oxygen uptake, which the abstract reports as energy expenditure, was highest in the combined circuit (29.9 ± 3.6 ml/kg/min), then free weights (24.2 ± 2.8) and machines (20.4 ± 2.9). The combined circuit also gave the highest total energy expenditure, yet the lowest lactate and perceived exertion.

The anaerobic share of total energy was 6.2% with machines, 4.6% with free weights and 2.3% in the combined circuit.

The authors conclude that the combined circuit gives the highest oxygen consumption, that total energy expenditure varies with the type of exercise in the circuit, and that the anaerobic part, though modest, should be estimated, since leaving it out may underestimate total energy expenditure.

Participants

Not in the abstract: number, sex, age, body mass, training status or VO2max.
The PubMed indexing lists the age bands adolescent, young adult and adult.

Protocol

Randomised crossover: each participant did all three circuits in random order.
Each circuit: 3 sets of 8 exercises, 45 min 15 s, at 70% of 15RM.
Circuits: free-weight exercises; machine exercises; free-weight exercises alternated with aerobic exercise.
Measured throughout: oxygen uptake (aerobic energy) and lactate (to estimate anaerobic energy); perceived exertion.
Not in the abstract: the exercises, the aerobic stations, work and rest times, heart rate, the days between sessions.

Key Results

CircuitOxygen uptake, ml/kg/min (mean ± SD)Anaerobic share of total energy
Free weights alternated with aerobic exercise29.9 ± 3.62.3%
Free weights24.2 ± 2.84.6%
Machines20.4 ± 2.96.2%
Combined circuit: the highest total energy expenditure and the lowest lactate and perceived exertion.
The abstract labels the oxygen-uptake values "energy expenditure"; they are millilitres of oxygen per kg per minute, not kcal.
No heart-rate values in the abstract.

Practical Application

Mixing cardio stations into a weights circuit raised its oxygen cost and felt easier. Over 45 min at the same load, alternating free weights with aerobic exercise drew about 1.5 times the oxygen of a machine circuit (29.9 against 20.4 ml/kg/min; our arithmetic) with less lactate and lower perceived effort; free weights sat in between.
A weights-only circuit is mostly aerobic, at a modest rate. The anaerobic share was 6.2% or less in all three circuits. Inference, not tested here: read the 20.4-29.9 ml/kg/min against the athlete's own VO2max; for a fit endurance athlete it may be a modest fraction, so a weights circuit does not replace an aerobic session.
Inference, not tested here: heart rate in a circuit is a poor guide to its aerobic cost. This abstract gives no heart rates, but elsewhere the same RPE on different gym machines brought similar heart rates with very different energy costs (REF-1430), and wrist sensors read low during resistance training (REF-1249).
Not settled by this design: training effects over weeks (pooled in REF-1638), who the participants were, and whether the ranking holds at heavier loads; each circuit was done once.

Limitations

The participants are not described in the abstract: number, sex, age and fitness unknown.
Acute only: one session of each circuit, no training outcome.
Anaerobic energy is estimated from lactate, an indirect method.
Oxygen uptake is an absolute rate; its share of VO2max, and heart rate, are not in the abstract.
Written from the abstract and the PubMed record; full text not read.
How this entry was checked and changed
Why this level

crossover with the number of participants not in the abstract, so the ≥15 route to B+ cannot be checked; oxygen uptake during the session is what the entry is about, so no marker step

Content correction 2026-11-07
2026-11-07: added from the abstract and the PubMed record; level B (randomised crossover, number of participants not in the abstract).