REF-1447 · Meyler et al., 2023 · Experimental Physiology · Paper · PubMed · Free full text

Does a fixed % of VO2max put a heavy session in the right domain?

At 75% VO2max, 7 of 10 rode above critical power and 3 finished 20 min; set from thresholds, 10 of 10 did. Low-fit adults, one session; %VO2max, not %FTP.

Main caveat: Small and low-fit; n = 10 recreationally active adults, 3 women, no athletes.
limited evidenceMeasured on non-athletes and recreational people

Meyler and colleagues (University of Hertfordshire) asked whether prescribing exercise from physiological thresholds gives a more uniform stimulus than prescribing it from VO2max.

Ten adults did three visits of testing, then bouts in random order of prescription method: moderate (30 min at 90% of gas exchange threshold, GET, vs 55% of VO2max), heavy (20 min at GET + 50% of the gap to critical power, CP, vs 75% of VO2max) and HIIT (5 × 3 min at 110% of CP vs 85% of VO2max). All completed both moderate bouts.

In the heavy bout, the %VO2max prescription averaged 113 ± 13% of CP and 3 of 10 finished; the threshold prescription averaged 83 ± 6% of CP and 10 of 10 finished. The three who finished at 75% of VO2max were at 96-100% of CP; the seven who did not were at 101-132%. Average lactate was 8.06 vs 4.12 mmol/L. HIIT completion was 2 of 10 vs 10 of 10.

Variability in peak and average lactate and in W′ depletion was lower with thresholds for HIIT. Our reading: the clearest acute demonstration in the base that a percentage of a maximum can put one person in the heavy domain and another in the severe domain on the same prescription, in line with REF-038 (B+) and REF-1230 (A-).

It is the mechanism behind treating any percentage target as a starting guess. But the percentage tested is of VO2max in low-fit adults; nothing here measures %FTP.

Protocol

Participants: n = 10 (7 men, 3 women), 23 ± 6 y, VO2max 38 ± 4 mL/kg/min.
Testing: ramp test with verification for VO2max and GET; four constant-work-rate tests to estimate CP and W′ by the best-fitting of three models.
Bouts: cross-over; group 1 thresholds first, group 2 %VO2max first; bouts within a visit separated by 1 h of recovery, visits at least 24 h apart; participants blinded to condition.
Analysis: SDs compared with the F-distribution, F below 0.33 treated as a meaningful reduction in variability given n = 10; completion rates compared.
Funding and interests: "no funding"; the authors declare no conflicting interests.

Key Results

BoutWork rate (W)%CP (range)CompletedAverage lactate (mmol/L)Average HR (%HRmax)
Moderate, 90% GET102 ± 1560 ± 11 (45-79)100%2.43 ± 1.2071 ± 7
Moderate, 55% VO2max124 ± 1473 ± 9 (57-85)100%3.31 ± 1.2876 ± 5
Heavy, GET + 50% to CP143 ± 1883 ± 6 (75-94)100%4.12 ± 1.3082 ± 5
Heavy, 75% VO2max193 ± 19113 ± 13 (96-132)30%8.06 ± 2.8594 ± 5
HIIT, 110% CP190 ± 30110 ± 0100%6.50 ± 1.3091 ± 6
HIIT, 85% VO2max228 ± 23134 ± 15 (115-156)20%9.09 ± 2.3196 ± 6
Thresholds in this sample: GET 113 ± 17 W at 52 ± 4% VO2max; CP 172 ± 27 W at 69 ± 6% VO2max.
Variability in the heavy bout: no difference between methods in peak or average VO2, heart rate or lactate (lactate F = 0.361 and 0.403, above the 0.33 line), so the gain from thresholds in the heavy bout was tolerance and domain, not narrower group responses.
W′ used by the end of HIIT: 73 ± 22% at 85% of VO2max vs 30 ± 12% at 110% of critical power.

Mechanisms

Measured: at 75% of VO2max, those above CP reached about 95% of VO2max and 97% of HRmax; all at the threshold-based bout stayed below CP, ending about 76% of VO2max and 85% of HRmax.
Authors' interpretation: %VO2max "consistently overestimated the boundary between the heavy and severe intensity domains"; routine CP testing is encouraged; a more uniform stimulus could reduce variability in later adaptation, which they did not test.
Inference: a percentage target near the top of the heavy domain carries more risk of crossing the boundary than one lower down, because the boundary's position varies more than the prescription allows for.

Practical Application

Does a fixed % of VO2max put a heavy session in the right domain? At 75% VO2max, 7 of 10 rode above critical power and 3 finished 20 min; set from thresholds, 10 of 10 did. Low-fit adults, one session; %VO2max, not %FTP.
Setting a session below the ceiling: a measured boundary beats a percentage of a maximum here. Not from this paper; the base's own practice: treat a percent target as a starting guess and judge by feel, drift and lactate (REF-137, SYNTH-27).
What it does not show: that threshold-based prescription trains better over weeks (see REF-1230, A-, mostly untrained), anything about FTP percentages or a named band such as sweet spot, or results in trained athletes.

Limitations

Small and low-fit; n = 10 recreationally active adults, 3 women, no athletes.
Acute; one bout per condition, no training or adaptation.
Several bouts per visit with 1 h between them; carry-over between bouts is not excluded.
CP model-based, estimated from four tests with individual model selection.
Anchor is %VO2max, so transfer to %FTP is inference.
Funding: none; no conflicts declared.
How this entry was checked and changed
Why this level

the rubric's B for a crossover under 15; the outcome is completion and acute response in one session, not training adaptation

Full text (checked 2026-10-30)
Completion rates were lower for HVYTRAD compared to HVYTHR (30% vs. 100%, P < 0.001) and for HIITTRAD compared to HIITTHR (20% vs. 100%, P < 0.001) (full text)
Expressed as a percentage of CP, intensities ranged between 75% and 94% and 96% and 132% in HVYTHR and HVYTRAD, respectively (full text)
In the three individuals who completed HVYTRAD, the work rates associated with 75% V˙O2max were below or at CP (96–100% CP); in the seven individuals who were not able to complete HVYTRAD, work rates were all above CP (101–132% CP) (full text)
Power output at CP was 172 ± 27 W and occurred at 69 ± 6% V˙O2max; power output at GET was 113 ± 17 W and occurred at 52 ± 4% V˙O2max (full text)
HVYTHR BLaavg 4.12 ± 1.30, F 0.403; HVYTRAD BLaavg 8.06 ± 2.85 (full text)
There was no difference in the variability of peak or average V˙O2, HR or BLa between MODTHR and MODTRAD, or between HVYTHR and HVYTRAD (full text)
Participants: Males (n = 7), Females (n = 3), V˙O2max 38 ± 4 ml kg−1 min−1 (full text)
There was no funding used for the current research study; the authors declare that they have no conflicting interests (full text)